Skip to main content

Posts

Showing posts with the label cancer

Use recent gel nail:cancer headlines to discuss research design

 Many of my students love a good manicure.  Sometimes, they come in with full-on talons.  The youth love manicures.  As such, the recent viral headlines about gel nail polish lamps and cancer matter to them.  #scicomm But what did the original research really study? https://www.nature.com/articles/s41467-023-35876-8#Sec12 (CHECK OUT THIS GREAT RM IMAGE FROM THE ORIGINAL RESEARCH!!!) This  short NPR story by Rachel Treisman  is a great summary. The NPR audio story is accompanied by a written report. In that report, Treisman succinctly summarizes the methodology: https://www.npr.org/2023/01/26/1151332361/gel-nails-cancer-manicure-safe 1. Let's talk about science communication. The NPR story is accurate science reporting. However, most of the headlines don't mention that a) some of the evidence came from mice cells, and they measured cell mutations but not cancer.  2. Let's talk about factorial ANOVA The researchers used a 3 (cell types: human 1, hu...

Watson's For Women Over 30, There May Be A Better Choice Than The Pap Smear

Emily Watson, writing for NPR, describes medical research by Ogilvie, vanNiekerk, & Krajden . This research provides a timely, topical example of false positives, false negatives, medical research, and gets your students thinking a bit more flexibly about measurement. This research provides valuable information about debate in medicine: What method of cervical cancer detection is most accurate: The traditional Pap smear, or an HPV screening? The Pap smear works by scraping cells off of a cervix and having a human view and detect abnormal cervical cancer cells. The HPV test, indeed, detects HPV. Since HPV causes 99% of cervical cancers, its presence signals a clinician to perform further screen, usually a colonoscopy. The findings: Women over 30 benefit more from the HPV test. How to use this example in class: - This is a great example of easy-to-follow  research methodology and efficacy testing in medicine. A question existed: Which is better, Pap or HPV test? The questi...

Moderation, esophageal cancer, and really hot tea.

You know what, I've been doing this blog for YEARS and I don't have a single example of moderation. Until now. This CNN story summarizes brand new research findings that indicate that alcohol and/or tobacco use mediate the relationship between drinking really hot tea and developing esophageal cancer. So, the really hot tea-cancer relationship does not exist in the absence of smoking and/or alcohol consumption, but it is there if you do indulge in either smoking or alcohol consumption. And writing this post reminded me of this Arrested Development moment: Aside: -This article could also be a good example of the need for cross cultural research: Americans don't love tea as much as other parts of the world do. And, super hot tea (145 degrees +) is very popular outside of the US and Europe. The present research was conducted in China.

Harris's "Scientists Are Not So Hot At Predicting Which Cancer Studies Will Succeed"

This NPR story is about reproducibility in science that ISN'T psychology, the limitations of expert intuition, and the story is a summary of a recent research article from PLOS Biology  (so open science that isn't psychology, too!). Thrust of the story: Cancer researchers may be having a similar problem to psychologists in terms of replication.  I've blogged this issue before. In particular, concerns with replication in cancer research, possibly due to the variability with which lab rats are housed and fed . So, this story is about a study in which 200 cancer researchers, post-docs, and graduate students took a look at six pre-registered cancer stud y replications and guessed which studies would successfully replicate. And the participants systematically overestimated the likelihood of replication. However, researchers with high h-indices, were more accurate that the general sample. I wonder if the high h-indicies uncover super-experts or super-researchers who have be...

Christie Aschwanden's "The Case Against Early Cancer Detection"

I love counterintuitive data that challenges commonly held beliefs. And there is a lot of counterintuitive health data out there (For example, data questioning the health benefits associated with taking vitamins  or data that lead to a revolution in how we put our babies to sleep AND cut incidents of SIDS in half ). This story by Aschwanden for fivethirtyeight.com discusses efficacy data for various kinds of cancer screening. Short version of this article: Early cancer screening detects non-cancerous lumps and abnormalities in the human body, which in turn leads to additional and evasive tests and procedures in order to ensure that an individual really is cancer-free or to remove growths that are not life-threatening (but expose an individual to all the risks associated with surgery). Specific Examples: 1) Diagnosis of thyroid cancer in South Korea has increased. Because it is being tested more often. However, death due to thyroid cancer has NOT increased (see figure below)...

Amanda Aronczyk's "Cancer Patients And Doctors Struggle To Predict Survival"

Warning: This isn't an easy story to listen to, as it is about life expectancy and terminal cancer (and how doctors can best convey such information to their patients). Most of this news story is dedicated to training doctors on the best way to deliver this awful news.   But Aronczyk, reporting for NPR, does tell a story that provides a good example of high-stakes applied statistics . Specifically, when explaining life expectancy to patients with terminal cancer, which measure of central tendency should be used? See the quote from the story below to understand where confusion and misunderstanding can come from measures of central tendency. " The data are typically given as a median, which is different from an average. A median is the middle of a range. So if a patient is told she has a year median survival, it means that half of similar patients will be alive at the end of a year and half will have died. It's possible that the person's cancer will advance quic...